Pharmacynamics cov khoom no yog acetanilide antipyretic analgesics. Los ntawm kev txwv tsis pub loj los ntawm cyclooxygenase, xaiv inhibition ntawm hypothalamic thermular dilatation, tawm hws thiab antipyretic nyhuv thiab aspirin zoo sib xws; by inhibiting the synthesis of prostaglandins and other And release, improve pain threshold and play an analgesic effect, are peripheral analgesics, the role of aspirin than weak, only mild to moderate pain effective. Cov khoom no tsis muaj kev cuam tshuam los tiv thaiv kev ua kom pom tseeb.
Pharmaconininetics tom qab kev tswj hwm lub plab los ntawm kev nqus cov khoom noj kom haum rau cov khoom nqus tau sai sai, yog li 25% thiab ntshav protein khi. Ib qho me me (ntshav ntau<60μg / ml) and protein binding is not obvious, a large number or a large amount of poisoning rate is higher, up to 43%. 90 ~ 95% of the goods in the liver metabolism, mainly with glucuronic acid, sulfuric acid and cysteine binding. The intermediate metabolites have toxic effects on the liver. Half-life β is generally 1 to 4 hours (2 hours on average), renal insufficiency, but in some patients with liver disease may be extended, the elderly and newborns may be extended, children are shortened. 0.5 to 2 hours after oral administration of plasma concentration up to the peak, the dose of 650mg or less when the plasma concentration of 5 ~ 20μg / ml, the duration of 3 to 4 hours. Lactation during the women taking the goods 650mg, 1 to 2 hours reported milk concentration of 10 ~ 15μg / ml; half-life β is 1.35 ~ 3.5 hours. The goods mainly with glucuronic acid in the form of excretion from the kidneys, about 24 hours within about 3% with the original shape with the urine.
